Estrogen receptor variant messenger RNA lacking exon 4 in estrogen-responsive human breast cancer cell lines.

@article{Pfeffer1993EstrogenRV,
  title={Estrogen receptor variant messenger RNA lacking exon 4 in estrogen-responsive human breast cancer cell lines.},
  author={Ulrich Pfeffer and Emanuela Fecarotta and Luigi A M Castagnetta and G Vidali},
  journal={Cancer research},
  year={1993},
  volume={53 4},
  pages={741-3}
}
We have identified a messenger RNA coding for a variant estrogen receptor jointly expressed with the normal mRNA in the estrogen receptor-positive, -responsive mammary carcinoma cell lines MCF-7 and ZR 75-1 by means of reverse transcription polymerase chain reaction. This variant mRNA was not observed in estrogen receptor-negative, -unresponsive MDA-MB 231 cells. Partial sequence analysis of the variant complementary DNA revealed identity to sequences of the estrogen receptor exons 3, 5, and 6… CONTINUE READING