Estrogen receptor null mice: what have we learned and where will they lead us?

@article{Couse1999EstrogenRN,
  title={Estrogen receptor null mice: what have we learned and where will they lead us?},
  author={John F. Couse and Kenneth S. Korach},
  journal={Endocrine reviews},
  year={1999},
  volume={20 3},
  pages={358-417}
}
All scientific investigations begin with distinct objectives: first is the hypothesis upon which studies are undertaken to disprove, and second is the overall aim of obtaining further information, from which future and more precise hypotheses may be drawn. Studies focusing on the generation and use of gene-targeted animal models also apply these goals and may be loosely categorized into sequential phases that become apparent as the use of the model progresses. Initial studies of knockout models… CONTINUE READING
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