Estrogen receptor-mediated regulation of oxidative stress and DNA damage in breast cancer.

@article{Mobley2004EstrogenRR,
  title={Estrogen receptor-mediated regulation of oxidative stress and DNA damage in breast cancer.},
  author={James A. Mobley and Robert W. Brueggemeier},
  journal={Carcinogenesis},
  year={2004},
  volume={25 1},
  pages={3-9}
}
Estrogens have been implicated to be complete carcinogens in breast and gynecologic tissues. Possible mechanisms may include differential metabolism with subsequent formation of reactive oxygen species and/or a receptor-mediated pathway, which may also involve indirect modulation of intracellular redox state. Estrogen-mediated oxidative DNA damage in mammary gland epithelia includes the induction of 8-oxo-2'-deoxyguanosine, both in vitro and in vivo, thereby suggesting a role for oxidative… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 54 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 51 references

17Beta-estradiol is carcinogenic in human breast epithelial cells.

The Journal of steroid biochemistry and molecular biology • 2002

Estrogen and the risk of breast cancer.

The New England journal of medicine • 2001

Endogenous estrogens as carcinogens through metabolic activation.

Journal of the National Cancer Institute. Monographs • 2000

Similar Papers

Loading similar papers…