Estrogen receptor-mediated cross-talk with growth factor signaling pathways

@article{Kato2001EstrogenRC,
  title={Estrogen receptor-mediated cross-talk with growth factor signaling pathways},
  author={Shigehiko Kato},
  journal={Breast Cancer},
  year={2001},
  volume={8},
  pages={3-9}
}
Estrogen (E2) palys critical roles in the development of tumors in female reproductive organs. Development of most breast cancers is dependent on E2 in most cases. Most E2 actions are considered to be exerted through two subtypes of Estrogen receptors (ERs), ER α and ER β. ERs belong to the nuclear receptor superfamily, and act as ligand-inducible transcription factors to activate transcription of a particular set of the target genes. Ligand-bound ER recruits at least two distinct classes of… CONTINUE READING

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