Estrogen receptor-mediated, nitric oxide-dependent modulation of the immunologic barrier function of the endothelium: regulation of fas ligand expression by estradiol.

Abstract

BACKGROUND Premenopausal women have a lower incidence of coronary artery disease than postmenopausal women or same-age men. Although the mechanisms of this apparent relative protection against atherosclerosis remain ill defined, estradiol, which is present in higher concentrations before menopause, is considered to play a central role. Recently, Fas ligand… (More)

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@article{Amant2001EstrogenRN, title={Estrogen receptor-mediated, nitric oxide-dependent modulation of the immunologic barrier function of the endothelium: regulation of fas ligand expression by estradiol.}, author={Christine Amant and P. Holm and S H Xu Sh and N Tritman and M. Kearney and Douglas W. Losordo}, journal={Circulation}, year={2001}, volume={104 21}, pages={2576-81} }