Estrogen receptor interaction with estrogen response elements.

@article{Klinge2001EstrogenRI,
  title={Estrogen receptor interaction with estrogen response elements.},
  author={Carolyn M Klinge},
  journal={Nucleic acids research},
  year={2001},
  volume={29 14},
  pages={
          2905-19
        }
}
The estrogen receptor (ER) is a ligand-activated enhancer protein that is a member of the steroid/nuclear receptor superfamily. Two genes encode mammalian ER: ERalpha and ERbeta. ER binds to specific DNA sequences called estrogen response elements (EREs) with high affinity and transactivates gene expression in response to estradiol (E(2)). The purpose of this review is to summarize how natural and synthetic variations in the ERE sequence impact the affinity of ER-ERE binding and E(2)-induced… CONTINUE READING

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Selectivity of detection of estrogen receptors α and β with cognate antibodies in electrophoretic mobility shift assay

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