Estrogen receptor expression in human breast cancer associated with an estrogen receptor gene restriction fragment length polymorphism.

@article{Hill1989EstrogenRE,
  title={Estrogen receptor expression in human breast cancer associated with an estrogen receptor gene restriction fragment length polymorphism.},
  author={Susan M Hill and Suzanne A W Fuqua and Gary C. Chamness and Geoffrey L Greene and William L. McGuire},
  journal={Cancer research},
  year={1989},
  volume={49 1},
  pages={145-8}
}
Estrogen receptor (ER) content is a well-known predictor of clinical outcome in human breast cancer. The recent cloning of a human ER complementary DNA has made possible the characterization of the ER gene on a molecular level. We have examined in human breast cancers a single, two-allele restriction fragment length polymorphism using the restriction enzyme PvuII. Initial studies in human breast cancer cell lines suggested a possible association between the absence of one allele and the absence… CONTINUE READING

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Pvull RFLP inside the human estrogen receptor gene

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1 Excerpt

The progesterone receptor gene maps to human chromosome band Ilql3, the site of the mammary oncogene int-2

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2 Excerpts

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