Estrogen-receptor-dependent regulation of telomerase activity in human endometrial cancer cell lines.

@article{Boggess2006EstrogenreceptordependentRO,
  title={Estrogen-receptor-dependent regulation of telomerase activity in human endometrial cancer cell lines.},
  author={John F. Boggess and Chunxiao Zhou and Victoria L. Bae-Jump and Paola A. Gehrig and Young E. Whang},
  journal={Gynecologic oncology},
  year={2006},
  volume={103 2},
  pages={417-24}
}
OBJECTIVES Given that prolonged exposure to unopposed estrogen is associated with endometrial cancer development and that the promoter region of the catalytic subunit of the telomerase enzyme, hTERT, contains putative estrogen response elements (EREs), we postulated that estrogen-receptor (ER)-mediated induction of telomerase activity may play an important role in endometrial carcinogenesis. METHODS ER-positive and ER-negative endometrial cancer cell lines were used. ER alpha expression was… CONTINUE READING
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