Estrogen receptor beta1 and the beta2/betacx isoforms in nonneoplastic endometrium and in endometrioid carcinoma.

@article{Chakravarty2007EstrogenRB,
  title={Estrogen receptor beta1 and the beta2/betacx isoforms in nonneoplastic endometrium and in endometrioid carcinoma.},
  author={Dimple Chakravarty and Radhika Srinivasan and SukhenC. Ghosh and Sarala Gopalan and Arvind Rajwanshi and Shyama Majumdar},
  journal={International journal of gynecological cancer : official journal of the International Gynecological Cancer Society},
  year={2007},
  volume={17 4},
  pages={
          905-13
        }
}
Estrogen receptor beta (ERbeta) has five carboxyl-terminal (C-terminal) isoforms derived from alternative splicing. ERbeta1 is the wild-type receptor whereas ERbeta2/betacx lacks the activation function (AF)-2 core essential for ligand-dependent transcriptional activation and so behaves as a dominant-negative receptor affecting the function of ERalpha. The objective of this study was to analyze the expression of ERbeta1 and ERbeta2/betacx isoforms in nonneoplastic endometrium and endometrioid… CONTINUE READING
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