Estrogen receptor-beta mediates male-female differences in the development of pressure overload hypertrophy.

@article{Skavdahl2005EstrogenRM,
  title={Estrogen receptor-beta mediates male-female differences in the development of pressure overload hypertrophy.},
  author={Maryanne Skavdahl and Charles Steenbergen and James Clark and P. M. Myers and Tracy Demianenko and Lan Mao and Howard A Rockman and Kenneth S. Korach and Elizabeth Murphy},
  journal={American journal of physiology. Heart and circulatory physiology},
  year={2005},
  volume={288 2},
  pages={H469-76}
}
The goal of this study was to determine the role of estrogen receptor subtypes in the development of pressure overload hypertrophy in mice. Epidemiological studies have suggested gender differences in the development of hypertrophy and heart disease, but the mechanism and the role of estrogen receptor subtypes are not established. We performed transverse aortic constriction (TAC) and sham operations in male and female wild-type (WT) mice and mice lacking functional estrogen receptor-alpha… CONTINUE READING
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