Estrogen receptor beta increases the efficacy of antiestrogens by effects on apoptosis and cell cycling in breast cancer cells

@article{HodgesGallagher2007EstrogenRB,
  title={Estrogen receptor beta increases the efficacy of antiestrogens by effects on apoptosis and cell cycling in breast cancer cells},
  author={Leslie Hodges-Gallagher and Cathleen D. Valentine and Suzy El Bader and Peter J. Kushner},
  journal={Breast Cancer Research and Treatment},
  year={2007},
  volume={109},
  pages={241-250}
}
Clinical evidence indicates that higher levels of estrogen receptor beta (ERβ) predicts improved disease-free and overall survival in patients treated with adjuvant tamoxifen therapy. To better understand the mechanisms in which ERβ can modulate breast cancer therapies, we introduced ERβ under an inducible promoter into MCF-7 breast cancer cells. In these cells, induction of ERβ expression led to a shift in the potency and an increase in the efficacy of tamoxifen to inhibit proliferation. A… CONTINUE READING

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