Estrogen receptor beta decreases survival of p53-defective cancer cells after DNA damage by impairing G2/M checkpoint signaling
@article{Thomas2010EstrogenRB, title={Estrogen receptor beta decreases survival of p53-defective cancer cells after DNA damage by impairing G2/M checkpoint signaling}, author={C. Thomas and A. Strom and K. Lindberg and J. Gustafsson}, journal={Breast Cancer Research and Treatment}, year={2010}, volume={127}, pages={417-427} }
Estrogen receptor beta (ERβ) inhibits proliferation in different cellular systems by regulating components of the cell cycle machinery. Eukaryotic cells respond to DNA damage by arresting in G1, S, or G2 phases of the cell cycle to initiate DNA repair. Most tumor cells due to disruptions in the p53-dependent G1 pathway are dependent on S-phase and G2/M checkpoints to maintain genomic integrity in response to DNA damage. We report that induction of ERβ expression causes abrogation of the S-phase… CONTINUE READING
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References
SHOWING 1-10 OF 46 REFERENCES
p53-deficient cells rely on ATM- and ATR-mediated checkpoint signaling through the p38MAPK/MK2 pathway for survival after DNA damage.
- Biology, Medicine
- Cancer cell
- 2007
- 535
- PDF
BRCA1 activates a G2-M cell cycle checkpoint following 6-thioguanine-induced DNA mismatch damage.
- Biology, Medicine
- Cancer research
- 2007
- 34
- PDF
Participation of p53 protein in the cellular response to DNA damage.
- Biology, Medicine
- Cancer research
- 1991
- 3,841
- PDF
Estrogen Receptor β Inhibits Human Breast Cancer Cell Proliferation and Tumor Formation by Causing a G2 Cell Cycle Arrest
- Biology
- Cancer Research
- 2004
- 483
- PDF
Estrogen receptor beta inhibits human breast cancer cell proliferation and tumor formation by causing a G2 cell cycle arrest.
- Medicine
- Cancer research
- 2004
- 273
- Highly Influential
Therapeutic Exploitation of Checkpoint Defects in Cancer Cells Lacking p53 Function
- Biology, Medicine
- Cell cycle
- 2002
- 81
- Highly Influential
Chk1 Suppresses a Caspase-2 Apoptotic Response to DNA Damage that Bypasses p53, Bcl-2, and Caspase-3
- Medicine
- Cell
- 2008
- 215
Loss of BRCA1 function increases the antitumor activity of cisplatin against human breast cancer xenografts in vivo
- Biology, Medicine
- Cancer biology & therapy
- 2009
- 82
Recent Advances in Cancer Therapy Targeting Proteins Involved in DNA Double-Strand Break Repair
- Biology, Medicine
- Clinical Cancer Research
- 2009
- 186
- PDF
Tumor Suppressor p53 Is Required To Modulate BRCA1 Expression
- Biology, Medicine
- Molecular and Cellular Biology
- 2000
- 84
- Highly Influential
- PDF