Estrogen receptor beta decreases survival of p53-defective cancer cells after DNA damage by impairing G2/M checkpoint signaling

@article{Thomas2010EstrogenRB,
  title={Estrogen receptor beta decreases survival of p53-defective cancer cells after DNA damage by impairing G2/M checkpoint signaling},
  author={Christoforos Thomas and Anders M. Strom and Karolina Lindberg and Jan-{\AA}ke Gustafsson},
  journal={Breast Cancer Research and Treatment},
  year={2010},
  volume={127},
  pages={417-427}
}

• Christoforos Thomas, Anders M. Strom, +1 author Jan-Åke Gustafsson
• Published 2010 in Breast Cancer Research and Treatment
• DOI:10.1007/s10549-010-1011-z

Estrogen receptor beta (ERβ) inhibits proliferation in different cellular systems by regulating components of the cell cycle machinery. Eukaryotic cells respond to DNA damage by arresting in G1, S, or G2 phases of the cell cycle to initiate DNA repair. Most tumor cells due to disruptions in the p53-dependent G1 pathway are dependent on S-phase and G2/M checkpoints to maintain genomic integrity in response to DNA damage. We report that induction of ERβ expression causes abrogation of the S-phase… CONTINUE READING

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