Estrogen receptor beta and ovarian cancer: a key to pathogenesis and response to therapy

  title={Estrogen receptor beta and ovarian cancer: a key to pathogenesis and response to therapy},
  author={Ioannis Kyriakidis and P. Papaioannidou},
  journal={Archives of Gynecology and Obstetrics},
  • Ioannis Kyriakidis, P. Papaioannidou
  • Published 2016
  • Medicine
  • Archives of Gynecology and Obstetrics
  • AbstractIntroduction Ovarian cancer remains the leading cause of mortality due to gynecological tumors. Estrogen receptors (ERs) seem to participate in tumor progression even in the absence of estrogens. Twenty years after the cloning of the second estrogen receptor, a wide spectrum of studies have shown its implication in both physiologic and pathologic pathways. ERβ, being the predominant type of ER in normal ovary tissue, has not only been linked with pathogenesis of ovarian cancer, but also… CONTINUE READING
    16 Citations
    The expression of transcription factor BORIS and its association with the estrogen receptor beta (ER-β) in cervical carcinogenesis.
    • 1
    • PDF
    Endometriosis Malignant Transformation: Epigenetics as a Probable Mechanism in Ovarian Tumorigenesis
    • 8
    • PDF


    Potential Role of Estrogen Receptor Beta as a Tumor Suppressor of Epithelial Ovarian Cancer
    • 75
    • PDF
    Loss of ERbeta expression as a common step in estrogen-dependent tumor progression.
    • 419
    • PDF
    Mitochondrial estrogen receptor β2 drives antiapoptotic pathways in advanced serous ovarian cancer.
    • 10
    Hormone receptors as a marker of poor survival in epithelial ovarian cancer.
    • 41
    Estrogen receptor beta, a possible tumor suppressor involved in ovarian carcinogenesis.
    • 133