Estrogen receptor alpha signaling in inflammatory leukocytes is dispensable for 17beta-estradiol-mediated inhibition of experimental autoimmune encephalomyelitis.

@article{Garidou2004EstrogenRA,
  title={Estrogen receptor alpha signaling in inflammatory leukocytes is dispensable for 17beta-estradiol-mediated inhibition of experimental autoimmune encephalomyelitis.},
  author={Lucile Garidou and Sophie Laffont and Victorine Douin-Echinard and Christiane Coureau and Andr{\'e}e Krust and Pierre Chambon and J Guery},
  journal={Journal of immunology},
  year={2004},
  volume={173 4},
  pages={2435-42}
}
Estrogen treatment has been shown to exert a protective effect on experimental autoimmune encephalomyelitis (EAE), and is under clinical trial for multiple sclerosis. Although it is commonly assumed that estrogens exert their effect by modulating immune functions, we show in this study that 17beta-estradiol (E2) treatment can inhibit mouse EAE without… CONTINUE READING