Estrogen receptor alpha negative breast cancer patients: estrogen receptor beta as a therapeutic target.


Clinical management of breast cancer is increasingly guided by assessment of tumor phenotypic parameters. One of these is estrogen receptor (ER) status, currently defined by ERalpha expression. However with the discovery of a second ER, ERbeta and its variant isoforms, the definition of ER status is potentially more complex. In breast tumors there are two… (More)
DOI: 10.1016/j.jsbmb.2007.12.010