Estrogen receptor alpha mediates epithelial to mesenchymal transition, expression of specific matrix effectors and functional properties of breast cancer cells.

@article{Bouris2015EstrogenRA,
  title={Estrogen receptor alpha mediates epithelial to mesenchymal transition, expression of specific matrix effectors and functional properties of breast cancer cells.},
  author={Panagiotis Bouris and Spyros S. Skandalis and Zoi Piperigkou and Nikos A. Afratis and Konstantina Karamanou and Alexios J. Aletras and Aristidis Moustakas and Achilleas D. Theocharis and Nikos K Karamanos},
  journal={Matrix biology : journal of the International Society for Matrix Biology},
  year={2015},
  volume={43},
  pages={42-60}
}
The 17β-estradiol (E2)/estrogen receptor alpha (ERα) signaling pathway is one of the most important pathways in hormone-dependent breast cancer. E2 plays pivotal roles in cancer cell growth, survival, and architecture as well as in gene expression regulatory mechanisms. In this study, we established stably transfected MCF-7 cells by knocking down the ERα gene (designated as MCF-7/SP10+ cells), using specific shRNA lentiviral particles, and compared them with the control cells (MCF-7/c… CONTINUE READING
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