Estrogen receptor-alpha mRNA in primary breast cancer: relationship to estrogen and progesterone receptor proteins and other prognostic factors.

@article{Chearskul2002EstrogenRM,
  title={Estrogen receptor-alpha mRNA in primary breast cancer: relationship to estrogen and progesterone receptor proteins and other prognostic factors.},
  author={Supornpim Chearskul and Kris Bhothisuwan and Malika Churintrapun and Namoiy Semprasert and Smarn Onreabroi},
  journal={Asian Pacific journal of allergy and immunology},
  year={2002},
  volume={20 1},
  pages={13-21}
}
The estrogen receptor (ER)-alpha protein and ER mRNA were measured in 314 primary breast cancer patients by enzyme immunoassay (EIA) and reverse-transcription polymerase chain reaction (RT-PCR) assay, respectively. The positivity of ER protein was 53% while of ER mRNA was 37.6%. A significant positive association between ER phenotype and ER mRNA was observed (r = 0.40, p < 0.0001) with a positive-negative agreement between them of 71.8%. The percentage of ER-negative, progesterone receptor (PR… CONTINUE READING
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