Estrogen receptor alpha is required in GABAergic , but not glutamatergic , neurons to masculinize the brain

Masculinization of the rodent brain is driven by estrogen signaling during a perinatal critical period. Genetic deletion of estrogen receptor alpha (Esr1/ERa) results in altered hypothalamicpituitary-gonadal (HPG) axis signaling and a dramatic reduction of male sexual and territorial behaviors. However, the requirement of ERa function in masculinizing… CONTINUE READING