Estrogen receptor alpha is required for mammary development and the induction of mammary hyperplasia and epigenetic alterations in the aromatase transgenic mice.

@article{Tekmal2005EstrogenRA,
  title={Estrogen receptor alpha is required for mammary development and the induction of mammary hyperplasia and epigenetic alterations in the aromatase transgenic mice.},
  author={Rajeshwar Rao Tekmal and Ya-Guang Liu and Hareesh B. Nair and Jeremy O Jones and Rao P Perla and Dennis B. Lubahn and Kenneth S. Korach and Nameer Kirma},
  journal={The Journal of steroid biochemistry and molecular biology},
  year={2005},
  volume={95 1-5},
  pages={9-15}
}
Aromatase transgenic mice exhibit hyperplastic and dysplastic changes, attesting to the importance of local estrogen in breast carcinogenesis. These mice also show increased levels of the estrogen receptor alpha and beta (ERalpha, ERbeta) suggesting that this receptor may play an important role in the initiation of estrogen-mediated mammary hyperplasia observed in these mice. To address the specific role of ERalpha in the mammary development and in the induction of estrogen-mediated hyperplasia… CONTINUE READING

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