Estrogen receptor alpha is necessary in thymic development and estradiol-induced thymic alterations.

@article{Staples1999EstrogenRA,
  title={Estrogen receptor alpha is necessary in thymic development and estradiol-induced thymic alterations.},
  author={Jennifer Staples and Thomas A Gasiewicz and Nancy C. Fiore and Dennis B. Lubahn and Kenneth S. Korach and Allen E. Silverstone},
  journal={Journal of immunology},
  year={1999},
  volume={163 8},
  pages={4168-74}
}
Estrogens affect the development, maturation, and function of multiple organ systems, including the immune system. One of the main targets of estrogens in the immune system is the thymus, which undergoes atrophy and phenotypic alterations when exposed to elevated levels of estrogen. To determine how estrogens influence the thymus and affect T cell development, estrogen receptor alpha (ERalpha) knockout (ERKO) mice were examined. ERKO mice have significantly smaller thymi than their wild-type… CONTINUE READING
37 Citations
0 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 37 extracted citations

Similar Papers

Loading similar papers…