Estrogen receptor alpha is a major mediator of 17beta-estradiol's atheroprotective effects on lesion size in Apoe-/- mice.

@article{Hodgin2001EstrogenRA,
  title={Estrogen receptor alpha is a major mediator of 17beta-estradiol's atheroprotective effects on lesion size in Apoe-/- mice.},
  author={Jeffrey B. Hodgin and John H. Krege and Robert Lee Reddick and Kenneth S. Korach and Oliver Smithies and Nobuyo N. Maeda},
  journal={The Journal of clinical investigation},
  year={2001},
  volume={107 3},
  pages={333-40}
}
The inhibitory effects of estrogen (17beta-estradiol) on atherosclerosis have been well documented in numerous animal models, and epidemiological evidence supports this protective effect in humans. The detailed mechanisms for this protection are not understood, but most are thought to be mediated through estrogen receptors (ERs), of which two are known (ERalpha and ERbeta). To investigate the role of ERalpha in the atheroprotective effect of 17beta-estradiol (E2), we ovariectomized female mice… CONTINUE READING