Estrogen receptor alpha genotype is associated with a reduced prevalence of radiographic hip osteoarthritis in elderly Caucasian women.

@article{Lian2007EstrogenRA,
  title={Estrogen receptor alpha genotype is associated with a reduced prevalence of radiographic hip osteoarthritis in elderly Caucasian women.},
  author={K Lian and Li-yung L Lui and Joseph M. Zmuda and Michael C. Nevitt and Marc C. Hochberg and Jocelyn M Lee and Jia Ning Li and Nancy E. Lane},
  journal={Osteoarthritis and cartilage},
  year={2007},
  volume={15 8},
  pages={972-8}
}
PURPOSE This study evaluated the association between polymorphisms in the estrogen receptor (ER) alpha gene (ESR1) and prevalent and incident radiographic hip osteoarthritis (RHOA) in a large, well-defined prospective cohort of elderly Caucasian women. METHODS Prevalent and incident RHOA was evaluated from all available pelvis X-rays obtained from the Study of Osteoporotic Fractures at baseline and after a mean of 8.3 years. Evaluable DNA samples were available from 4746 of these subjects… CONTINUE READING

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