Estrogen receptor alpha gene haplotype is associated with radiographic osteoarthritis of the knee in elderly men and women.

@article{Bergink2003EstrogenRA,
  title={Estrogen receptor alpha gene haplotype is associated with radiographic osteoarthritis of the knee in elderly men and women.},
  author={Arjan P Bergink and Joyce B. J. van Meurs and John Loughlin and Pascal P. Arp and Yue Fang and Albert Hofman and Johannes P. T. M van Leeuwen and Cornelia M van Duijn and Andr{\'e} G. Uitterlinden and Huibert A. P. Pols},
  journal={Arthritis and rheumatism},
  year={2003},
  volume={48 7},
  pages={1913-22}
}
OBJECTIVE Genetic influences have been shown to play an important role in the etiology of osteoarthritis (OA), but the genes involved are ill-defined. We studied the association between polymorphisms in the estrogen receptor alpha (ERalpha) gene and the prevalence of radiographic OA of the knee. METHODS The study group comprised 1,483 men and women from the Rotterdam Study. Direct molecular haplotyping was used to determine the relationship between 2 polymorphisms in the ERalpha gene (the Pvu… CONTINUE READING
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