Estrogen receptor alpha controls gene expression via translational offsetting

  title={Estrogen receptor alpha controls gene expression via translational offsetting},
  author={Julie Lorent and Richard J Rebello and Vincent van Hoef and Mitchell G. Lawrence and Krzysztof J. Szkop and Eric Purwadinata. Kusnadi and Baila Samreen and Preetika Balanathan and Karin Scharmann and Itsuhiro Takizawa and Sebastian A Leidel and Gail P Risbridger and Ivan Topisirovic and Ola Larsson and Luc Furic},
Estrogen receptor alpha (ERα) activity is associated with increased cancer cell proliferation. Studies aiming to understand the impact of ERα on cancer-associated phenotypes have largely been limited to its transcriptional activity. Herein, we demonstrate that ERα coordinates its transcriptional output with selective modulation of mRNA translation. Importantly, translational perturbations caused by depletion of ERα largely manifest as "translational offsetting" of the transcriptome, whereby… CONTINUE READING

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