Estrogen receptor-alpha and endothelial nitric oxide synthase nuclear complex regulates transcription of human telomerase.

@article{Grasselli2008EstrogenRA,
  title={Estrogen receptor-alpha and endothelial nitric oxide synthase nuclear complex regulates transcription of human telomerase.},
  author={Annalisa Grasselli and Simona Nanni and Claudia Colussi and Aurora Aiello and Valentina Benvenuti and Gianluca Ragone and Fabiola Moretti and Ada Sacchi and Silvia Bacchetti and Carlo Gaetano and Maurizio Colognesi Capogrossi and Alfredo Pontecorvi and Antonella Farsetti},
  journal={Circulation research},
  year={2008},
  volume={103 1},
  pages={34-42}
}
We report that in endothelial cells, the angiogenic effect of 17beta-estradiol (E2) is inhibited by the estrogen receptor (ER) antagonist ICI or the NO synthase (NOS) inhibitor 7-nitroindazole via downregulation of hTERT, the telomerase catalytic subunit, suggesting that E2 and NO are involved in controlling hTERT transcription. Quantitative Real-Time PCR and chromatin immunoprecipitations in E2-treated human umbilical vein endothelial cells, showed recruitment of ERs on the hTERT promoter and… CONTINUE READING

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