Estrogen receptor alpha (Esr1) regulates aromatase (Cyp19a1) expression in the mouse brain.


OBJECTIVES Local estrogen production in the brain regulates critical functions including neuronal development, gonadotropin secretion and sexual behavior. In the mouse brain, a 36 kb distal promoter (l.f) regulates the Cyp19a1 gene that encodes aromatase, the key enzyme for estrogen biosynthesis. In vitro, promoter l.f interacts with estrogen receptor alpha… (More)


3 Figures and Tables