Estrogen receptor alpha: impact of ligands on intracellular shuttling and turnover rate in breast cancer cells.

@article{Leclercq2006EstrogenRA,
  title={Estrogen receptor alpha: impact of ligands on intracellular shuttling and turnover rate in breast cancer cells.},
  author={Guy Leclercq and M. Lacroix and Ioanna La{\"i}os and Guy Laurent},
  journal={Current cancer drug targets},
  year={2006},
  volume={6 1},
  pages={39-64}
}
Estrogen receptors (alpha and beta) are members of the steroid/thyroid nuclear receptors superfamily of ligand-dependent transcription factors. Impact of the alpha isoform of estrogen receptor (ER) on breast cancer etiology and progression is now well established. Current therapeutic strategy to treat ER-positive breast cancer relies on the blockade of ER trancriptional activity by antiestrogens. Data accumulated during the last five years on the mechanism of action of ER enable one to foresee… CONTINUE READING
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