Estrogen receptor activation and cardioprotection in ischemia reperfusion injury.

@article{Deschamps2010EstrogenRA,
  title={Estrogen receptor activation and cardioprotection in ischemia reperfusion injury.},
  author={Anne M. Deschamps and Elizabeth Murphy and Junhui Sun},
  journal={Trends in cardiovascular medicine},
  year={2010},
  volume={20 3},
  pages={73-8}
}
Premenopausal females have a comparably lower incidence of cardiovascular disease than their male counterparts. Although estrogen and activation of estrogen receptors (ERs) have been found to contribute to female protection, the complex mechanisms involved are unclear. Besides altering gene transcription, estrogen could elicit its cardioprotective effect via ER-mediated nongenomic signaling pathways. In addition to the two classic nuclear ER isoforms, ERα and ERβ, a G-protein coupled ER (GPR30… CONTINUE READING
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