Estrogen receptor-β signaling modulates epithelial barrier function.

@article{LooijervanLangen2011EstrogenRS,
  title={Estrogen receptor-$\beta$ signaling modulates epithelial barrier function.},
  author={Mirjam Looijer-van Langen and Naomi Hotte and Levinus Albert Dieleman and Eric J. Albert and Chris J.J. Mulder and Karen Lindhardt Madsen},
  journal={American journal of physiology. Gastrointestinal and liver physiology},
  year={2011},
  volume={300 4},
  pages={
          G621-6
        }
}
Impaired epithelial barrier function and estrogens are recognized as factors influencing inflammatory bowel disease (IBD) pathology and disease course. Estrogen receptor-β (ERβ) is the most abundant estrogen receptor in the colon and a complete absence of ERβ expression is associated with disrupted tight-junction formation and abnormal colonic architecture. The aim of this study was to determine whether ERβ signaling has a role in the maintenance of epithelial permeability in the colon. ER… 
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