Estrogen receptor-β mRNA variants in human and murine tissues

@article{Lu1998EstrogenRM,
  title={Estrogen receptor-$\beta$ mRNA variants in human and murine tissues},
  author={Biao Lu and Etienne Leygue and Helmut Dotzlaw and Liam J. Murphy and P H Watson},
  journal={Molecular and Cellular Endocrinology},
  year={1998},
  volume={138},
  pages={199-203}
}
Expression of Estrogen Receptor-β and Its Variants in Normal Mammary and Tumor Tissues
TLDR
The decrease of ER-β2 and ER- β4 expression is prominent in cancer tissue especially in ER-α-positive cancers, which suggests that ER- α mRNA expression significantly increases butER-β mRNA expression decreases in the cancer tissues compared to the corresponding normal tissues.
Distribution of Estrogen Receptor Subtypes, Expression of Their Variant Forms, and Clinicopathological Characteristics of Human Colorectal Cancer
TLDR
Examining the expression of estrogen receptor (ER) messenger RNAs in colorectal tumor samples and corresponding normal mucosa found that in all patients the two ER subtype mRNAs were coexpressed in wild-type form, suggesting that the ER-β mRNA levels are independent of the tumor characteristics.
Transcriptional ratio of estrogen receptor β mRNAs in carcinomas and in normal tissues
TLDR
It is shown that ratio ERβ1/ERβΔ5 in breast cancer and cell line MDA MB 361 is increased compared to healthy tissue, and this finding suggests that decreasing of ERβ΢5 may be one of the phenomena related to tumorigenesis in estrogen responsive tissues and points to possible application of this type of analysis in future standard clinical practice.
Altered expression of estrogen receptor-α variant messenger RNAs between adjacent normal breast and breast tumor tissues
TLDR
Data demonstrate that changes in the relative expression of ER-α variant messenger RNAs occur between adjacent normal and neoplastic breast tissues and suggest that these changes might be involved in the mechanisms that underlie breast tumorigenesis.
Altered Estrogen Receptor α and β Messenger RNA Expression during Human Breast Tumorigenesis
TLDR
The results suggest that the role of ER-a- and ER-AŸ-driven pathways and/or their interaction change during breast tumorigenesis.
Functional characteristics of a novel murine estrogen receptor-beta isoform, estrogen receptor-beta 2.
TLDR
The isolation of a highly expressed splice variant mRNA of murine estrogen receptor-beta, mERbeta2, containing an in-frame 54 nucleotide insertion between exons 5 and 6 of wild-type m ERbeta1, suggests that the mER beta2 may have some tissue-specific and promoter-specific modulatory effects.
Expression of estrogen receptor β wt isoform (ERβ1) and ERβΔ5 splice variant mRNAs in sporadic breast cancer
TLDR
This is the first study in which ERβΔ5 mRNA splice variant was quantified by real-time RT-PCR in the clinical samples of breast cancer tissue, suggesting that the uncontrolled local tumor growth may occur as the expression of ERβ Δ5 mRNA decreases in estrogen-dependent breast cancer.
Progesterone receptor mRNA variant containing novel exon insertions between exon 4 and exon 5 in human uterine endometrium.
TLDR
The results demonstrate the presence of a novel PR mRNA variant with exon insertions in the human tissue for the first time and suggest that the i45 PR variant protein, possibly transcribed from this i45PR mRNA variant, may play physiological and/or pathological roles in thehuman uterine endometrium.
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References

SHOWING 1-10 OF 17 REFERENCES
Novel mutations in the estrogen receptor messenger RNA in human breast cancers.
TLDR
The data suggest nucleotide insertions are present in ER mRNA of some breast tumors and it is unknown if these novel ER-like mRNAs are stably translated in vivo.
Estrogen receptor variants in normal human mammary tissue.
TLDR
Several ER variant mRNAs are present in normal human breast tissue, but the level of expression of some of these variants may be lower in normal tissue than in tumor tissue, suggesting that the mechanisms generating ER variantmRNAs exist in normal breast tissue and may be deregulated in breast cancer tissues.
Variant estrogen receptor mRNA species detected in human breast cancer biopsy samples.
TLDR
The possibility that abnormal ER proteins may be associated with this endocrine resistant phenotype is investigated and the presence of abnormally sized ER mRNA in human breast tumor biopsies is looked for.
Oestrogen receptor variants and mutations in human breast cancer.
TLDR
The following review focuses on the current knowledge available in the scientific literature with respect to the type and characteristics of oestrogen receptor variants and mutations that have been identified as occurring naturally in human breast tissues and cell lines.
Cloning, chromosomal localization, and functional analysis of the murine estrogen receptor beta.
TLDR
The results demonstrate that while ER beta shares many of the functional characteristics of ER alpha, the molecular mechanisms regulating the transcriptional activity of mER beta may be distinct from those of ERalpha.
Detection of wild type and exon 5-deleted splice variant oestrogen receptor (ER) mRNA in ER-positive and -negative breast cancer cell lines by reverse transcription/polymerase chain reaction.
TLDR
The presence of exon 5-deleted V form ER mRNA in addition to the WT form in all four breast cancer cell lines may allow these lines to be used to assess differential regulation of transcription and the impact of this on their oestrogen dependence.
Absence of Glucocorticoid Receptor-β in Mice*
TLDR
Two human glucocorticoid receptor (GR) isoforms, GRα and GRβ, are derived from the same gene by alternative splicing involving exon 9 of the GR locus, but since GRβ is not conserved across species its physiological significance in humans appears questionable.
Cloning of a novel receptor expressed in rat prostate and ovary.
TLDR
It is concluded that clone 29 cDNA encodes a novel rat ER, which is suggested be named rat ERbeta to distinguish it from the previously cloned ER (ERalpha) from rat uterus.
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