Estrogen receptor β ligand therapy activates PI3K/Akt/mTOR signaling in oligodendrocytes and promotes remyelination in a mouse model of multiple sclerosis.

Abstract

The identification of a drug that stimulates endogenous myelination and spares axon degeneration during multiple sclerosis (MS) could potentially reduce the rate of disease progression. Using experimental autoimmune encephalomyelitis (EAE), a mouse model of MS, we have previously shown that prophylactic administration of the estrogen receptor (ER) β ligand… (More)
DOI: 10.1016/j.nbd.2013.04.005

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@article{Kumar2013EstrogenR, title={Estrogen receptor β ligand therapy activates PI3K/Akt/mTOR signaling in oligodendrocytes and promotes remyelination in a mouse model of multiple sclerosis.}, author={S. Niranjan Kumar and Rhusheet Patel and Spencer Moore and Daniel Crawford and Nirut Suwanna and Mario Mangiardi and Seema K. Tiwari-Woodruff}, journal={Neurobiology of disease}, year={2013}, volume={56}, pages={131-44} }