Estrogen receptor-β in the paraventricular nucleus and rostroventrolateral medulla plays an essential protective role in aldosterone/salt-induced hypertension in female rats.

@article{Xue2013EstrogenRI,
  title={Estrogen receptor-β in the paraventricular nucleus and rostroventrolateral medulla plays an essential protective role in aldosterone/salt-induced hypertension in female rats.},
  author={Baojian Xue and Zhongming Zhang and Terry G. Beltz and Ralph F. Johnson and Fang Guo and Meredith Hay and Alan Kim Johnson},
  journal={Hypertension},
  year={2013},
  volume={61 6},
  pages={1255-62}
}
The identification of the specific estrogen receptor (ER) subtypes that are involved in estrogen protection from hypertension and their specific locations in the central nervous system is critical to our understanding and design of effective estrogen replacement therapies in women. Using selective ER agonists and recombinant adeno-associated virus (AAV) carrying small interference (si) RNA to silence either ERα (AAV-siRNA-ERα) or ERβ (AAV-siRNA-ERβ), the present study investigated regional… CONTINUE READING

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American journal of physiology. Renal physiology • 2009

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