Estrogen receptor β in the paraventricular nucleus of hypothalamus regulates the neuroendocrine response to stress and is regulated by corticosterone

@article{Isgor2003EstrogenR,
  title={Estrogen receptor $\beta$ in the paraventricular nucleus of hypothalamus regulates the neuroendocrine response to stress and is regulated by corticosterone},
  author={Ceylan Isgor and Marco Cecchi and Mohamed Kabbaj and Huda Akil and Stanley J. Watson},
  journal={Neuroscience},
  year={2003},
  volume={121},
  pages={837-845}
}
The function of the second nuclear estrogen receptor, estrogen receptor beta (ERbeta), in the brain is largely unknown. The present study tested whether 1) ERbeta in the paraventricular nucleus (PVN) of the hypothalamus has a direct role in the hypothalamic-pituitary-adrenal (HPA) axis-mediated stress function, and 2) whether corticosterone (CORT) can regulate ERbeta gene expression in the PVN in the intact, cycling female rat. To test the first hypothesis a pure estrogen receptor antagonist… Expand
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Regulation of estrogen receptor-beta expression in the female rat hypothalamus: differential effects of dexamethasone and estradiol.
TLDR
Results indicate that glucocorticoids and estrogen exert opposing regulatory influences on the ERbeta gene expression, which may represent a mechanism by which these steroids can alter the cellular sensitivity of ERbeta-expressing neurons to subsequent steroidal activation. Expand
Estrogen receptor beta in the brain: From form to function
TLDR
The studies implicate ERbeta as an important modulator of some non-reproductive neurobiological systems as well as the molecular and neuroanatomical targets of estrogen that are mediated by ERbeta remain to be determined. Expand
Intrahypothalamic estradiol modulates hypothalamus-pituitary-adrenal-axis activity in female rats.
TLDR
Central E2 modulates HPA-axis activity both in the basal state and during restraint stress, whereas during stress, it is mediated by both ERα and ERβ. Expand
Estrogen alters c-Fos response to immobilization stress in the brain of ovariectomized rats
TLDR
Comparisons of CNS patterns of c-Fos expression in response to immobilization stress in ovariectomized rats with placebo treatment and supplemented with 17beta-estradiol suggest that neuronal activities in these areas are influenced bidirectionally by systemic estrogen level. Expand
Unmasking the functional anatomy of medial preoptic nucleus-influences on the hypothalamic-pituitary-adrenal axis
TLDR
It is demonstrated that the integrity of the MPN is essential in maintaining the regulatory effects of testosterone on the brain's response to stress, and the findings suggest that androgens could act throughout the brain, and on a large assortment of brain regions that innervate the PVN. Expand
Cyclic estradiol replacement attenuates stress-induced c-Fos expression in the PVN of ovariectomized rats
TLDR
The dampening effect of estradiol on the excessive stress-induced activity in the paraventricular nucleus (PVN) may be beneficial for the animal in its response to chronic recurrent stress by reducing the output of the PVN. Expand
Effects of the Estrous Cycle and Ovarian Hormones on Central Expression of Interleukin-1 Evoked by Stress in Female Rats
TLDR
The results from the current study implicate a potential mechanism through which high availability of endogenous Pg during the metestrous stage increases ER-β sensitivity, which in turn attenuates the PVN IL-1 response to stress. Expand
Steroid receptor coactivator-2 expression in brain and physical associations with steroid receptors
TLDR
It is found that SRC-2 was highly expressed throughout the hippocampus, amygdala and hypothalamus, including the medial preoptic area, ventral medial nucleus (VMN), arcuate nucleus (ARC), bed nucleus of the stria terminalis, supraoptic nucleus and suprachiasmatic nucleus, and is expressed in many ER(alpha) containing cells in the hypothalamus. Expand
New roles for estrogen receptor β in behavior and neuroendocrinology
In this review we critically examine the data on functions of the estrogen receptor beta (ERbeta) in both behavior and neuroendocrinology. The influence of estradiol via the ERbeta has been assessed… Expand
Estrogen in the Paraventricular Nucleus Attenuates l-Glutamate–Induced Increases in Mean Arterial Pressure Through Estrogen Receptor &bgr; and NO
TLDR
It is demonstrated that E2 in the PVN attenuates the l-glutamate–induced pressor response and that this effect is mediated by ER&bgr;, NO produced by neuronal NO synthase and eNOS, and partly by &ggr;-aminobutyric acid. Expand
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