Estrogen receptor β in the paraventricular nucleus of hypothalamus regulates the neuroendocrine response to stress and is regulated by corticosterone

@article{Isgor2003EstrogenR,
  title={Estrogen receptor $\beta$ in the paraventricular nucleus of hypothalamus regulates the neuroendocrine response to stress and is regulated by corticosterone},
  author={Ceylan Isgor and Marco Cecchi and Mohamed Kabbaj and Huda Akil and Stanley J. Watson},
  journal={Neuroscience},
  year={2003},
  volume={121},
  pages={837-845}
}
The function of the second nuclear estrogen receptor, estrogen receptor beta (ERbeta), in the brain is largely unknown. The present study tested whether 1) ERbeta in the paraventricular nucleus (PVN) of the hypothalamus has a direct role in the hypothalamic-pituitary-adrenal (HPA) axis-mediated stress function, and 2) whether corticosterone (CORT) can regulate ERbeta gene expression in the PVN in the intact, cycling female rat. To test the first hypothesis a pure estrogen receptor antagonist… Expand
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