Estrogen receptor β in the paraventricular nucleus of hypothalamus regulates the neuroendocrine response to stress and is regulated by corticosterone
@article{Isgor2003EstrogenR, title={Estrogen receptor β in the paraventricular nucleus of hypothalamus regulates the neuroendocrine response to stress and is regulated by corticosterone}, author={C. Isgor and M. Cecchi and M. Kabbaj and H. Akil and S. Watson}, journal={Neuroscience}, year={2003}, volume={121}, pages={837-845} }
The function of the second nuclear estrogen receptor, estrogen receptor beta (ERbeta), in the brain is largely unknown. The present study tested whether 1) ERbeta in the paraventricular nucleus (PVN) of the hypothalamus has a direct role in the hypothalamic-pituitary-adrenal (HPA) axis-mediated stress function, and 2) whether corticosterone (CORT) can regulate ERbeta gene expression in the PVN in the intact, cycling female rat. To test the first hypothesis a pure estrogen receptor antagonist… CONTINUE READING
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References
SHOWING 1-10 OF 44 REFERENCES
Regulation of estrogen receptor beta mRNA in the brain: opposite effects of 17beta-estradiol and the phytoestrogen, coumestrol.
- Biology, Medicine
- Brain research. Molecular brain research
- 1999
- 146
Estrogen modulates oxytocin gene expression in regions of the rat supraoptic and paraventricular nuclei that contain estrogen receptor-beta.
- Medicine, Biology
- Progress in brain research
- 2002
- 83
Correlation of estrogen beta-receptor messenger RNA with endogenous levels of plasma estradiol and progesterone in the female rat hypothalamus, the bed nucleus of stria terminalis and the medial amygdala.
- Biology, Medicine
- Brain research. Molecular brain research
- 2002
- 31
Vasopressin and the regulation of hypothalamic-pituitary-adrenal axis function: implications for the pathophysiology of depression.
- Medicine
- Life sciences
- 1998
- 259
Distribution of estrogen receptor β immunoreactivity in the rat central nervous system
- Biology, Medicine
- The Journal of comparative neurology
- 2001
- 457
Differential Regulation of Corticotropin-Releasing Hormone and Vasopressin Gene Transcription in the Hypothalamus by Norepinephrine
- Biology, Medicine
- The Journal of Neuroscience
- 1999
- 88
- PDF
Colocalization of estrogen β-receptor messenger RNA with orphanin FQ, vasopressin and oxytocin in the rat hypothalamic paraventricular and supraoptic nuclei
- Biology, Medicine
- Anatomy and Embryology
- 2003
- 30
- PDF
Dexamethasone suppresses estrogen action at the pituitary level without modulating estrogen receptor dynamics.
- Biology, Medicine
- Journal of steroid biochemistry
- 1985
- 11
Gonadal Steroids Exert Facilitating and “Buffering” Effects on Glucocorticoid-Mediated Transcriptional Regulation of Corticotropin-Releasing Hormone and Corticosteroid Receptor Genes in Rat Brain
- Biology, Medicine
- The Journal of Neuroscience
- 1996
- 120
- PDF
Distribution of estrogen receptor-beta-like immunoreactivity in rat forebrain.
- Chemistry, Medicine
- Neuroendocrinology
- 1997
- 268