Estrogen receptor β expression and androgen receptor phosphorylation correlate with a poor clinical outcome in hormone-naive prostate cancer and are elevated in castration-resistant disease.

@article{Zellweger2013EstrogenR,
  title={Estrogen receptor β expression and androgen receptor phosphorylation correlate with a poor clinical outcome in hormone-naive prostate cancer and are elevated in castration-resistant disease.},
  author={Tobias Zellweger and Susanne St{\"u}rm and Silvia Rey and Inti Zlobec and Joel Roman Gsponer and Cyrill A. Rentsch and Luigi Maria Terracciano and Alexander Bachmann and Lukas Bubendorf and Christian Ruiz},
  journal={Endocrine-related cancer},
  year={2013},
  volume={20 3},
  pages={403-13}
}
Patients with advanced prostate cancer (PC) are usually treated with androgen withdrawal. While this therapy is initially effective, nearly all PCs become refractory to it. As hormone receptors play a crucial role in this process, we constructed a tissue microarray consisting of PC samples from 107 hormone-naïve (HN) and 101 castration-resistant (CR) PC patients and analyzed the androgen receptor (AR) gene copy number and the protein expression profiles of AR, Serin210-phosphorylated AR (pAR… CONTINUE READING
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