Estrogen receptor-α signaling in osteoblast progenitors stimulates cortical bone accrual.

@article{Almeida2013EstrogenRS,
  title={Estrogen receptor-α signaling in osteoblast progenitors stimulates cortical bone accrual.},
  author={Maria de F{\'a}tima Menezes Santos Almeida and Srividhya Sundararaman Iyer and Marta Martin-Millan and Shoshana M. Bartell and Li Han and Elena Ambrogini and Melda Onal and Jinhu Xiong and Robert S. Weinstein and Robert L. Jilka and C A O'brien and Stavros C Manolagas},
  journal={The Journal of clinical investigation},
  year={2013},
  volume={123 1},
  pages={394-404}
}
The detection of estrogen receptor-α (ERα) in osteoblasts and osteoclasts over 20 years ago suggested that direct effects of estrogens on both of these cell types are responsible for their beneficial effects on the skeleton, but the role of ERα in osteoblast lineage cells has remained elusive. In addition, estrogen activation of ERα in osteoclasts can only account for the protective effect of estrogens on the cancellous, but not the cortical, bone compartment that represents 80% of the entire… CONTINUE READING
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