Estrogen receptor α mediates proliferation of breast cancer MCF-7 cells via a p21/PCNA/E2F1-dependent pathway.

@article{Liao2014EstrogenR,
  title={Estrogen receptor α mediates proliferation of breast cancer MCF-7 cells via a p21/PCNA/E2F1-dependent pathway.},
  author={Xing-Hua Liao and Da-Lin Lu and Nan Wang and Long-Yue Liu and Yue Wang and Yan-Qi Li and Ting-Bao Yan and Xue-Guang Sun and Peng Hu and Tong-Cun Zhang},
  journal={The FEBS journal},
  year={2014},
  volume={281 3},
  pages={
          927-42
        }
}
High expression of estrogen receptor α (ERα) is associated with a poor prognosis that correlates closely with cellular proliferation in breast cancer. However, the exact molecular mechanism by which ERα controls breast cancer cell proliferation is not clear. Here we report that ERα regulates the cell cycle by suppressing p53/p21 and up-regulating proliferating cell nuclear antigen (PCNA) and proliferation-related Ki-67 antigen (Ki-67) to promote proliferation of MCF-7 cells. In addition, 17… CONTINUE READING
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