Estrogen receptor-α is required by the supporting somatic cells for spermatogenesis

@article{Mahato2001EstrogenRI,
  title={Estrogen receptor-α is required by the supporting somatic cells for spermatogenesis},
  author={Dipak Mahato and Eugenia H. Goulding and Kenneth S. Korach and Edward M. Eddy},
  journal={Molecular and Cellular Endocrinology},
  year={2001},
  volume={178},
  pages={57-63}
}
Abstract The gene for estrogen receptor-alpha (ERα) was disrupted in embryonic stem cells by homologous recombination and these cells were used to generate mice with a targeted mutation in the ERα gene (αERKO mice). It was found that males homozygous for the mutation are infertile, indicating that estrogen signaling through this nuclear hormone receptor is required for male reproductive function. Although spermatogenesis appears normal in juvenile and young adult αERKO mice, the sperm produced… CONTINUE READING

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