Estrogen receptor α in osteocytes regulates trabecular bone formation in female mice.

@article{Kondoh2014EstrogenR,
  title={Estrogen receptor α in osteocytes regulates trabecular bone formation in female mice.},
  author={Shino Kondoh and Kazuki Inoue and Katsuhide Igarashi and Hiroe Sugizaki and Yuko Shirode-Fukuda and Erina Inoue and Taiyong Yu and Jun Takeuchi and Jun Kanno and Lynda F. Bonewald and Yuuki Imai},
  journal={Bone},
  year={2014},
  volume={60},
  pages={68-77}
}
Estrogens are well known steroid hormones necessary to maintain bone health. In addition, mechanical loading, in which estrogen signaling may intersect with the Wnt/β-catenin pathway, is essential for bone maintenance. As osteocytes are known as the major mechanosensory cells embedded in mineralized bone matrix, osteocyte ERα deletion mice (ERα(ΔOcy/ΔOcy)) were generated by mating ERα floxed mice with Dmp1-Cre mice to determine the role of ERα in osteocytes. Trabecular bone mineral density of… CONTINUE READING
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