Estrogen receptor (ER) mRNA expression and molecular subtype distribution in ER-negative/progesterone receptor-positive breast cancers

@article{Itoh2013EstrogenR,
  title={Estrogen receptor (ER) mRNA expression and molecular subtype distribution in ER-negative/progesterone receptor-positive breast cancers},
  author={Mitsuya Itoh and Takayuki Iwamoto and J. A. Matsuoka and Tomohiro Nogami and Takayuki Motoki and Tadahiko Shien and Naruto Taira and Naoki Niikura and Naoki Hayashi and Shoichiro Ohtani and Kenji Higaki and Toshiyoshi Fujiwara and Hiroyoshi Doihara and W. Fraser Symmans and Lajos Pusztai},
  journal={Breast Cancer Research and Treatment},
  year={2013},
  volume={143},
  pages={403-409}
}
We examined estrogen receptor (ER) mRNA expression and molecular subtypes in stage I–III breast cancers that are progesterone receptor (PR) positive but ER and HER2 negative by immunohistochemistry (IHC) or fluorescent in situ hybridization. The ER, PR, and HER2 status was determined by IHC as part of routine clinical assessment (N = 501). Gene expression profiling was done with the Affymetrix U133A gene chip. We compared expressions of ESR1 and MKI67 mRNA, distribution of molecular subtypes by… CONTINUE READING
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