Estrogen receptor (ER) mRNA and ER-related gene expression in breast cancers that are 1% to 10% ER-positive by immunohistochemistry.

@article{Iwamoto2012EstrogenR,
  title={Estrogen receptor (ER) mRNA and ER-related gene expression in breast cancers that are 1% to 10% ER-positive by immunohistochemistry.},
  author={Takayuki Iwamoto and Daniel J. Booser and Vicente Valero and James Murray and Kimberly B. Koenig and Francisco J. Esteva and Naoto T Ueno and Jie Zhang and Weiwei Shi and Yuan Alan Qi and J. A. Matsuoka and Elliana J Yang and Gabriel N Hortobagyi and Christos Hatzis and W. Fraser Symmans and Lajos Pusztai},
  journal={Journal of clinical oncology : official journal of the American Society of Clinical Oncology},
  year={2012},
  volume={30 7},
  pages={729-34}
}
PURPOSE We examined borderline estrogen receptor (ER) -positive cancers, defined as having 1% to 10% positivity by immunohistochemistry (IHC), to determine whether they show the same global gene-expression pattern and high ESR1 mRNA expression as ER-positive cancers or if they are more similar to ER-negative cancers. PATIENTS AND METHODS ER status was determined by IHC in 465 primary breast cancers and with the Affymetrix U133A gene chip. We compared expressions of ESR1 mRNA and a 106 probe… CONTINUE READING
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