Estrogen receptor (ER) and its messenger ribonucleic acid expression in the genital tract of female mice exposed neonatally to tamoxifen and diethylstilbestrol.

@article{Sato1996EstrogenR,
  title={Estrogen receptor (ER) and its messenger ribonucleic acid expression in the genital tract of female mice exposed neonatally to tamoxifen and diethylstilbestrol.},
  author={Tomoyuki Sato and Yasuhiko Ohta and Hitoshi Okamura and Shinichi Hayashi and Taisen Iguchi},
  journal={The Anatomical record},
  year={1996},
  volume={244 3},
  pages={374-85}
}
BACKGROUND Tamoxifen (Tx) is known as an antiestrogen because of its competitive inhibition of estrogen binding to estrogen receptor (ER), and it is used as an estrogen antagonist in the human breast. However, Tx is known to have estrogen agonist activity in the human fetal reproductive tracts and vaginal epithelium and endometrium of postmenopausal women as has been known in the mouse uterus. Therefore, we examined estrogenic potency of Tx on the uterus and vagina in newborn mice and adult… CONTINUE READING

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