Estrogen receptor, epidermal growth factor receptor and cellular ploidy in elutriated subpopulations of hepatocytes during liver tumor promotion by 17 alpha-ethinylestradiol in rats.

@article{Vickers1991EstrogenRE,
  title={Estrogen receptor, epidermal growth factor receptor and cellular ploidy in elutriated subpopulations of hepatocytes during liver tumor promotion by 17 alpha-ethinylestradiol in rats.},
  author={Alison E.M. Vickers and George W. Lucier},
  journal={Carcinogenesis},
  year={1991},
  volume={12 3},
  pages={
          391-9
        }
}
17 alpha-Ethinylestradiol (EE2)-mediated promotion of diethylnitrosamine (DEN)-initiated liver tumors was evaluated in distinct hepatocyte subpopulations. Our initiation-promotion regime consisted of a single dose of DEN (200 mg/kg) to ovariectomized rats, followed by chronic exposure to EE2 (90 micrograms/kg/day for 30 weeks). We observed significant increases in liver and uterine organ wts which were associated with liver tumor formation. Isolated hepatocytes were separated by elutriation… CONTINUE READING
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