Estrogen protects primary osteocytes against glucocorticoid-induced apoptosis

  title={Estrogen protects primary osteocytes against glucocorticoid-induced apoptosis},
  author={Guowei Gu and Teuvo A. Hentunen and Martin Nars and Pirkko L. H{\"a}rk{\"o}nen and H. Kalervo. V{\"a}{\"a}n{\"a}nen},
Glucocorticoid-induced osteoporosis may be at least in part due to the increased apoptosis of osteocytes. To study the role of osteocyte apoptosis in glucocorticoid-induced osteoporosis, we isolated primary osteocytes from murine calvaria for the analysis of the effects of dexamethasone in in vitro culture. The cells were identified by morphology, cytochemical staining, immunocytochemical staining and mRNA expression of phosphate-regulating gene with homology to endopeptidases on the X… CONTINUE READING


Publications citing this paper.
Showing 1-10 of 34 extracted citations


Publications referenced by this paper.
Showing 1-10 of 59 references

Mechanically regulated expression of a neural glutamate transporter in bone: A role for 594 Apoptosis

  • DJ Mason, LJ Suva, PG Genever
  • 2005

Similar Papers

Loading similar papers…