Estrogen protects against beta-amyloid-induced neurotoxicity in rat hippocampal neurons by activation of Akt.

@article{Zhang2001EstrogenPA,
  title={Estrogen protects against beta-amyloid-induced neurotoxicity in rat hippocampal neurons by activation of Akt.},
  author={Li Zhang and David R Rubinow and G Xaing and B S Li and Yoong Hee Chang and Dragan Maric and Jeffery L. Barker and Wu Ma},
  journal={Neuroreport},
  year={2001},
  volume={12 9},
  pages={1919-23}
}
The cellular mechanisms underlying the neuroprotective effects of estrogen are only beginning to be elucidated. Here we examined the role of protein kinase B (Akt) activation in 17beta-estradiol (E2) inhibition of beta-amyloid peptide (31-35) (Abeta31-35)-induced neurotoxicity in cultured rat hippocampal neurons. Abeta31-35 (25-30 betaM) significantly decreased the total number of microtubule associated protein-2 positive cells (MAP2+). This decrease was significantly reversed by pre-treatment… CONTINUE READING