Estrogen protection against bone resorbing effects of parathyroid hormone infusion. Assessment by use of biochemical markers.

@article{Cosman1993EstrogenPA,
  title={Estrogen protection against bone resorbing effects of parathyroid hormone infusion. Assessment by use of biochemical markers.},
  author={Felicia Cosman and Victor Shen and Fuming Xie and M R Seibel and Anthony Ratcliffe and Robert F. Lindsay},
  journal={Annals of internal medicine},
  year={1993},
  volume={118 5},
  pages={337-43}
}
OBJECTIVE Because parathyroid hormone (PTH) stimulates bone resorption, resistance to its actions might help maintain bone mass. We tested the hypothesis that the effects of estrogen on bone are accomplished in part by decreasing the sensitivity of the skeleton to the resorbing effects of PTH. STUDY DESIGN Comparison of response to PTH infusion in untreated and estrogen-treated postmenopausal women with osteoporosis. INTERVENTION (1-34) human PTH, 0.55 U/(kg.h), was infused intravenously… CONTINUE READING