Estrogen promotes ER-negative tumor growth and angiogenesis through mobilization of bone marrow-derived monocytes.

@article{Iyer2012EstrogenPE,
  title={Estrogen promotes ER-negative tumor growth and angiogenesis through mobilization of bone marrow-derived monocytes.},
  author={Vandana Iyer and Ina Klebba and Jessica McCready and Lisa M. Arendt and Monica Betancur-Boissel and Meng-fen Wu and Xiaomei Zhang and Michael T. Lewis and Charlotte Kuperwasser},
  journal={Cancer research},
  year={2012},
  volume={72 11},
  pages={
          2705-13
        }
}
Estrogen has a central role in the genesis and progression of breast cancers whether they are positive or negative for the estrogen receptor (ER). While therapies that disrupt estrogen biosynthesis or ER activity can treat these diseases in postmenopausal women, in younger women where ovarian function remains intact, these anti-estrogen therapies are not as effective. Moreover, emerging clinical evidence suggests that estrogen may promote other cancers. Thus, circulating estrogens may… CONTINUE READING

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