Estrogen promotes B cell activation in vitro through down-regulating CD80 molecule expression.

@article{Fu2011EstrogenPB,
  title={Estrogen promotes B cell activation in vitro through down-regulating CD80 molecule expression.},
  author={Yibing Fu and Li Li and Xiaowen Liu and Chunyan Ma and Jie Ming Zhang and Yulian Jiao and Li You and Zi-Jiang Chen and Yueran Zhao},
  journal={Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology},
  year={2011},
  volume={27 8},
  pages={593-6}
}
Estrogen is the main female hormone of women. It has diverse effects on cell growth, differentiation and homeostatic functions. Accumulated evidence has indicated that estrogen may regulate multiple immune functions and the immune status of women. However, there is little report on the effect of estrogen on mature B cell functions. In this study, we observed the effect of 17β-estradiol (E2) on the proliferation, apoptosis, antibody production and differentiation of splenic B cells of mice in… CONTINUE READING