Estrogen pretreatment increases arachidonic acid release by bradykinin stimulated normal human osteoblast-like cells.

@article{Cissel1996EstrogenPI,
  title={Estrogen pretreatment increases arachidonic acid release by bradykinin stimulated normal human osteoblast-like cells.},
  author={David S. Cissel and M. Dakshina Murty and Diana L. Whipkey and John David Blaha and Geoffrey M. Graeber and Philip E. Keeting},
  journal={Journal of cellular biochemistry},
  year={1996},
  volume={60 2},
  pages={
          260-70
        }
}
Eicosanoids are multifunctional autocrine/paracrine regulators of bone that are enzymatically derived from arachidonic acid (AA). The rate-limiting step in the eicosanoid biosynthetic pathways may be the release of AA from membrane glycerophospholipids by activated phospholipases. Free AA can serve as the substrate for cyclooxygenase(s) or lipoxygenases that catalyze the commitive steps in eicosanoid synthesis; alternatively, free AA may be used in reacylation processes, resulting in its… CONTINUE READING
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