Estrogen pathway polymorphisms and mammographic density.

  title={Estrogen pathway polymorphisms and mammographic density.},
  author={Isabelle Dumas and Caroline Diorio},
  journal={Anticancer research},
  volume={31 12},
Elevated mammographic density (MD) is strongly associated with breast cancer risk and the estrogen pathway has been proposed as a potential mechanism for this association. It has been repeatedly observed that several established estrogen-related factors associated with breast cancer risk, such as parity and hormone replacement therapy, are also associated with MD. However, the association of circulating estrogen levels (known to be strongly positively associated with breast cancer risk) with MD… CONTINUE READING