Estrogen modulates the sexually dimorphic synaptic connectivity of the ventromedial nucleus

  title={Estrogen modulates the sexually dimorphic synaptic connectivity of the ventromedial nucleus},
  author={Susana Isabel S{\'a} and Maria Dulce Madeira},
  journal={Journal of Comparative Neurology},
Neurons in the ventrolateral division of the hypothalamic ventromedial nucleus (VMNvl) display a remarkable estrogen‐dependent functional and structural plasticity, which is likely to be mediated, in part at least, by neuronal afferents. The present study was designed to determine whether the number of synapses per neuron and the size of individual synapses in the VMNvl vary across the estrus cycle and, also, whether they differ between the sexes. To accomplish this, the VMNvl of adult female… 

Sex differences in the dendritic arbor of hypothalamic ventromedial nucleus neurons



Male-female difference in synaptic organization of the ventromedial nucleus of the hypothalamus in the rat.

The results suggest that the synaptic organization in the VMN is sexually dimorphic but the occurrence of this structural difference is limited to the VL-VMN which is abundant in sex steroid receptors, and is modified by neonatal sex steroid environment.

Influence of sex and estrus cycle on the sexual dimorphisms of the hypothalamic ventromedial nucleus: Stereological evaluation and golgi study

The results reveal that the magnitude of the neuroanatomical sex differences in theVMN vary across the estrus cycle due to the trophic influence of estrogen upon its neurons, and show that the fundamental sex difference in the structure of the VMN is accounted for by the neuropil components.

Gonadal steroids modify dendritic spine density in ventromedial hypothalamic neurons: a Golgi study in the adult rat.

When spine density of VMN neurons was assessed throughout the estrous cycle, it was determined that spine density was significantly lower at diestrus than proestrus, and there were no differences between intact male and female rats observed in any parameter.

Arcuate nucleus of the hypothalamus: Effects of age and sex

The results show that the total number of neurons and the volume of the ARN are sexually dimorphic in adult and aged rats and that neither of these parameters is altered by aging.

Ultrastructure of neurons in the ventromedial nucleus or the hypothalamus in ovariectomized rats with or without estrogen treatment

In both VMN subdivisions, the increased stacking of the RER could be correlated with the greater number of dense-cored vesicles and may reflect increased biosynthesis of a secretory product.